Journal article
Exposure to household air pollution over 10 years is related to asthma and lung function decline
X Dai, DS Bui, JL Perret, AJ Lowe, PA Frith, G Bowatte, PS Thomas, GG Giles, GS Hamilton, H Tsimiklis, J Hui, J Burgess, AK Win, MJ Abramson, EH Walters, SC Dharmage, CJ Lodge
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2021
Abstract
Introduction: We investigated if long-term household air pollution (HAP) is associated with asthma and lung function decline in middle-aged adults, and whether these associations were modified by glutathione S-transferase (GST) gene variants, ventilation and atopy. Materials and methods: Prospective data on HAP (heating, cooking, mould and smoking) and asthma were collected in the Tasmanian Longitudinal Health Study (TAHS) at mean ages 43 and 53 years (n=3314). Subsamples had data on lung function (n=897) and GST gene polymorphisms (n=928). Latent class analysis was used to characterise longitudinal patterns of exposure. Regression models assessed associations and interactions. Results: We i..
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Grants
Awarded by Pfizer
Funding Acknowledgements
The TAHS is supported by grants from the National Health and Medical Research Council (NHMRC) of Australia, under the NHMRC grant scheme (299901, 1021275) and NHMRC European collaborative grant scheme (1101313) as part of ALEC (Aging Lungs in European Cohorts funded by the European Union's Horizon 2020 research and innovation programme under grant agreement number 633212), the Victorian, Queensland and Tasmanian Asthma Foundations, the Clifford Craig Medical Research Trust, the Royal Hobart Hospital Research Foundation, the University of Melbourne, Helen Macpherson Smith Trust, and GlaxoSmithKline.